Cape Town City will be without the services of Thabo Nodada and Roland Putsche for the remainder of the season after they were injured against Highlands Park.
Nodada and Putsche were both involved in some heavy tackles in last weekend's Nedbank Cup last-16 tie, and subsequently will play no part in the rest of the campaign.
Putsche came off first for Teko Modise in the 16th minute before Nodada followed in the 66th minute.
The club expressed their disappointment at the injury blow and lamented the quality of officiating in the Premiership.
The side's official Twitter account said: "Thabo Nodada has suffered a right leg fracture, and Roland Putsche a meniscus tear.
"We wish both a speedy recovery and stress repeated concern over the unpunished violent conduct in the PSL."